Structure of PDB 7us1 Chain A Binding Site BS01

Receptor Information
>7us1 Chain A (length=240) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPLGSSFFVYCKGPCHKVQPGKLRVQCGTCRQATLTLAQGPSCWDDVLIP
NRMSGECQSPDCPGTRAEFFFKCGAHPTSDKDTSVALNLITNNSRSIPCI
ACTDVRNPVLVFQCNHRHVICLDCFHLYCVTRLNDRQFVHDAQLGYSLPC
VAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGA
GLLPEQGQRKVTCEGGNGLGCGFVFCRDCKEAYHEGECDS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7us1 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7us1 Structure of the second phosphoubiquitin-binding site in parkin.
Resolution2.484 Å
Binding residue
(original residue number in PDB)		C253 H257 C289 C293
Binding residue
(residue number reindexed from 1)		C114 H118 C150 C154
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7us1, PDBe:7us1, PDBj:7us1
PDBsum7us1
PubMed35690145
UniProtQ9JK66|PRKN_RAT E3 ubiquitin-protein ligase parkin (Gene Name=Prkn)

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