Structure of PDB 7ure Chain A Binding Site BS01

Receptor Information
>7ure Chain A (length=432) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSYLKH
ASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTI
LIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGTVPSPV
EFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSCRWLQKVARSLALALLC
LVLSTCVGPYLFPYFIPLNARWLRAYESAVSFHFSNYFVGFLSEATATLA
GAGFTEEKDHLEWDLTVSKPLNVELPRSMVEVVTSWNLPMSYWLNNYVFK
NALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLA
RILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLAYLGSLFDV
YGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
Ligand information
>7ure Chain B (length=20) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
HLKCKCHGLAGSCEVKTCWW
Receptor-Ligand Complex Structure
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PDB7ure Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
Resolution3.19 Å
Binding residue
(original residue number in PDB)		C17 Q24 Q28 F68 H121 K122 I129 F167 L204 Y213 S249 V253
Binding residue
(residue number reindexed from 1)		C14 Q21 Q25 F65 H118 K119 I126 F164 L201 Y210 S235 V239
Enzymatic activity
Enzyme Commision number 2.3.1.250: [Wnt protein] O-palmitoleoyl transferase.
Gene Ontology
Molecular Function
GO:0016746 acyltransferase activity
GO:0017147 Wnt-protein binding
GO:1990698 palmitoleoyltransferase activity
Biological Process
GO:0006497 protein lipidation
GO:0009100 glycoprotein metabolic process
GO:0016055 Wnt signaling pathway
GO:0030258 lipid modification
GO:0045234 protein palmitoleylation
GO:0061355 Wnt protein secretion
GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0032281 AMPA glutamate receptor complex
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ure, PDBe:7ure, PDBj:7ure
PDBsum7ure
PubMed35831507
UniProtQ9H237|PORCN_HUMAN Protein-serine O-palmitoleoyltransferase porcupine (Gene Name=PORCN)

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