Structure of PDB 7uo2 Chain A Binding Site BS01

Receptor Information
>7uo2 Chain A (length=112) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLAFPRELRLLTPSQFTFVFQQPQRAGTPQITILGRLNSLGHPRIGLTVA
KKNVRRAHERNRIKRLTRESFRLRQHELPAMDFVVVAKKGVADLDNRALS
EALEKLWRRHCR
Ligand information
>7uo2 Chain B (length=271) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaagcugaccagacagucgccgcuucgucgucguccucuucgggggagac
gggcggaggggaggaaaguccgggcuccauagggcagggugccagguaac
gccugggggggaaacccacgaccaguaaacuccacccggagcaaggccaa
auagggguucauaagguacggcccguacugaacccggguaggcugcuuga
gccagugagcgauugcuggccuagaugaaugacuguccacgacagaaccc
ggcuuaucggucaguuucccu
<<<<<<<<<<.[.((....<<.<<<<<.<<<<.<<<<<....>>>>>>>>
>..>>>>>.>>.{...<<.<<<<<<<<<...<<<<.<<<<<<<<<<....
.>>>>>.<<......>>..<...<<<..>>>>>>>>>>>>>...<<<<..
.....((.(...........>>>>......).))......>>>>......
<<<<<<<<....>>>>>>>>.............))]......}....>>>
>>>>....>>>>>>>>>>...
Receptor-Ligand Complex Structure
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PDB7uo2 Structural and mechanistic basis for recognition of alternative tRNA precursor substrates by bacterial ribonuclease P.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K2 L3 A4 F5 L12 T13 P14 L48 T49 R57 A58 H59 R66 R69 E70 R73
Binding residue
(residue number reindexed from 1)		K1 L2 A3 F4 L11 T12 P13 L47 T48 R56 A57 H58 R65 R68 E69 R72
Enzymatic activity
Enzyme Commision number 3.1.26.5: ribonuclease P.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004526 ribonuclease P activity
GO:0042781 3'-tRNA processing endoribonuclease activity
Biological Process
GO:0001682 tRNA 5'-leader removal
GO:0006396 RNA processing
GO:0008033 tRNA processing
GO:0042780 tRNA 3'-end processing
Cellular Component
GO:0030677 ribonuclease P complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uo2, PDBe:7uo2, PDBj:7uo2
PDBsum7uo2
PubMed36045135
UniProtP0A7Y8|RNPA_ECOLI Ribonuclease P protein component (Gene Name=rnpA)

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