Structure of PDB 7um5 Chain A Binding Site BS01

Receptor Information
>7um5 Chain A (length=268) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLV
AALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDR
YWSITRPMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGS
EECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVEQKEQRAA
LMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFN
PLIYTAFNKNYNSAFKNF
Ligand information
Ligand ID8K3
InChIInChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15)
InChIKeyWKZLNEWVIAGNAW-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7c1cc2c(cc1C(=O)N)c(c[nH]2)CCN
CACTVS 3.385NCCc1c[nH]c2ccc(cc12)C(N)=O
FormulaC11 H13 N3 O
Name3-(2-azanylethyl)-1H-indole-5-carboxamide
ChEMBLCHEMBL18840
DrugBank
ZINCZINC000002539813
PDB chain7um5 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7um5 Inactive and active state structures template selective tools for the human 5-HT 5A receptor.
Resolution2.73 Å
Binding residue
(original residue number in PDB)		D121 C125 S204 E305
Binding residue
(residue number reindexed from 1)		D82 C86 S165 E221
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001586 Gi/o-coupled serotonin receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0030594 neurotransmitter receptor activity
GO:0051378 serotonin binding
GO:0099589 serotonin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0021766 hippocampus development
GO:0032355 response to estradiol
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0043204 perikaryon
GO:0099634 postsynaptic specialization membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7um5, PDBe:7um5, PDBj:7um5
PDBsum7um5
PubMed35835867
UniProtP47898|5HT5A_HUMAN 5-hydroxytryptamine receptor 5A (Gene Name=HTR5A)

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