Structure of PDB 7ulz Chain A Binding Site BS01

Receptor Information
>7ulz Chain A (length=521) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPRKILVTSALPYANGSIHLGHMLEYIQTDMWVRFQKMRGNQAVYVCADD
AHGSAIMLRAEREGITSEQLIDAVRAEHMGDFADFLVDFDNYHSTHSEEN
RELSSAIYLKLRDAGHIDTRPVTQYFDPEKQMFLADRFATYAPTELKSAI
SGATPVLKESLHYFFKLPDFEAMLKQWTRSGALQESVANKLAEWLDSGLQ
QWDISRDAPYFGFEIPDAPGKYFYVWLDAPIGYMASFKNLCARRPELDFD
AFWGKDSGAELYHFIGKDIVNFHALFWPAMLEGAGYRKPTALNVHGYLTV
NGQKMSKSRGTFVKARTYLDHLDPEYLRYYYASKLGRGVEDLDLNLEDFV
QKVNSDLVGKVVNIASRCAGFIHKGNAGVLVGADPAPELLAAFREAAPGI
AEAYEARDFNRAMREIMALADRANAWIAEQAPWALAKQEGQQDKVQAVCG
LGINLFRQLVIFLKPVLPKLAAAAEAFLNVAPLTWADHQTLLANHQLNPF
QPLMTRIEPAKVEAMIEASKE
Ligand information
Ligand IDMET
InChIInChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChIKeyFFEARJCKVFRZRR-BYPYZUCNSA-N
SMILES
SoftwareSMILES
CACTVS 3.341CSCC[CH](N)C(O)=O
OpenEye OEToolkits 1.5.0CSCCC(C(=O)O)N
CACTVS 3.341CSCC[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0CSCC[C@@H](C(=O)O)N
ACDLabs 10.04O=C(O)C(N)CCSC
FormulaC5 H11 N O2 S
NameMETHIONINE
ChEMBLCHEMBL42336
DrugBankDB00134
ZINCZINC000001532529
PDB chain7ulz Chain A Residue 608 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ulz Crystal Structure of Methionine-tRNA ligase / Methionyl-tRNA synthetase (MetRS) from Pseudomonas aeruginosa PAO1
Resolution2.8 Å
Binding residue
(original residue number in PDB)		L13 Y15 D52 W253 A256 P257 Y260 H300
Binding residue
(residue number reindexed from 1)		L11 Y13 D50 W226 A229 P230 Y233 H273
Annotation score5
Enzymatic activity
Enzyme Commision number 6.1.1.10: methionine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7ulz, PDBe:7ulz, PDBj:7ulz
PDBsum7ulz
PubMed
UniProtQ9HYC7|SYM_PSEAE Methionine--tRNA ligase (Gene Name=metG)

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