Structure of PDB 7ukh Chain A Binding Site BS01

Receptor Information

>7ukh Chain A (length=203) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQ
TWQDTLERYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGK
LHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDAD
QKKARLARIRAAKSGSANAYMQSKRNGSSFETQHHHLLHCLEKTTNHEFV
DEQ

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

7ukh Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7ukh Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Resolution	2.33 Å
Binding residue (original residue number in PDB)	H105 C132
Binding residue (residue number reindexed from 1)	H102 C129
Annotation score	1

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005216	monoatomic ion channel activity
GO:0005249	voltage-gated potassium channel activity

	Biological Process
GO:0006811	monoatomic ion transport
GO:0006813	potassium ion transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport

	Cellular Component
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane

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Cellular Component

External links

PDB	RCSB:7ukh, PDBe:7ukh, PDBj:7ukh
PDBsum	7ukh
PubMed	35597238
UniProt	Q9NZV8\|KCND2_HUMAN A-type voltage-gated potassium channel KCND2 (Gene Name=KCND2)

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