Structure of PDB 7uis Chain A Binding Site BS01

Receptor Information
>7uis Chain A (length=267) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQK
LEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY
YSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLAD
FGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYIL
LVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP
SKRITAAEALKHPWISH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7uis CaMKII binds both substrates and activators at the active site.
Resolution2.58 Å
Binding residue
(original residue number in PDB)		R52 E96 F98 N135 K137 E139 L159 F173 A174 G175 T176 G178 P211 W214 Q218 E236
Binding residue
(residue number reindexed from 1)		R46 E90 F92 N129 K131 E133 L153 F167 A168 G169 T170 G172 P205 W208 Q212 E230
Enzymatic activity
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7uis, PDBe:7uis, PDBj:7uis
PDBsum7uis
PubMed35830796
UniProtQ9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)

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