Structure of PDB 7uir Chain A Binding Site BS01

Receptor Information
>7uir Chain A (length=268) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQK
LEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY
YSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLAD
FGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYIL
LVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP
SKRITAAEALKHPWISHR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7uir CaMKII binds both substrates and activators at the active site.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		F98 E99 E105 K137 E139 G175 T176 P177 G178 I205 V208 G209 Y210 W214 P233 E236
Binding residue
(residue number reindexed from 1)		F92 E93 E99 K131 E133 G169 T170 P171 G172 I199 V202 G203 Y204 W208 P227 E230
Enzymatic activity
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7uir, PDBe:7uir, PDBj:7uir
PDBsum7uir
PubMed35830796
UniProtQ9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)

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