Structure of PDB 7uhi Chain A Binding Site BS01

Receptor Information
>7uhi Chain A (length=264) Species: 522373 (Stenotrophomonas maltophilia K279a) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APLPQLRAYTVDASWLQPMAPLQVADHTWQIGTEDLTALLVQTAEGAVLL
DGGMPQMAGHLLDNMKLRGVAPQDLRLILLSHAHADHAGPVAELKRRTGA
HVAANAETAVLLARGGSNDLHFGDGITYPPASADRIIMDGEVVTVGGIAF
TAHFMPGHTPGSTAWTWTDTRDGKPVRIAYADSLSAPGYQLKGNPRYPRL
IEDYKRSFATVRALPCDLLLTPHPGASNWNYAVGSKASAEALTCNAYADA
AEKKFDAQLARETA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7uhi Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7uhi Time-resolved beta-lactam cleavage by L1 metallo-beta-lactamase.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		H105 H107 H181
Binding residue
(residue number reindexed from 1)		H82 H84 H158
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7uhi, PDBe:7uhi, PDBj:7uhi
PDBsum7uhi
PubMed36450742
UniProtB2FTM1

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