Structure of PDB 7u5v Chain A Binding Site BS01
Receptor Information
>7u5v Chain A (length=124) Species:
9606
(Homo sapiens) [
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ALAAASAAAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKR
EKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINID
GQKHIVIFAMRKIYRGEELTYDYA
Ligand information
>7u5v Chain C (length=4) Species:
9606
(Homo sapiens) [
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VKRC
Receptor-Ligand Complex Structure
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PDB
7u5v
Crystal structure of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and Borealin peptide.
Resolution
2.59 Å
Binding residue
(original residue number in PDB)
Y3858 E3872 D3876 C3882 Y3883 M3884 F3885 R3886 R3903 Y3944
Binding residue
(residue number reindexed from 1)
Y37 E51 D55 C61 Y62 M63 F64 R65 R82 Y123
Enzymatic activity
Enzyme Commision number
2.1.1.-
2.1.1.364
: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB
RCSB:7u5v
,
PDBe:7u5v
,
PDBj:7u5v
PDBsum
7u5v
PubMed
37945831
UniProt
Q03164
|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)
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