Structure of PDB 7u50 Chain A Binding Site BS01

Receptor Information
>7u50 Chain A (length=96) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSA
VMALQEASEAYLVGLFEDTNLAAIHAKRVTIMPKDIQLARRIRGER
Ligand information
>7u50 Chain I (length=144) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgagaatcccggtgccgaggccgctcaattggtcgtagacagctctagca
ccgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaagggg
attactccctagtctccaggcacgtgtcagatatatccatccga
Receptor-Ligand Complex Structure
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PDB7u50 Structural basis for APE1 processing DNA damage in the nucleosome.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R42 R72 R83 F84 R116 T118 M120
Binding residue
(residue number reindexed from 1)		R4 R34 R45 F46 R78 T80 M82
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7u50, PDBe:7u50, PDBj:7u50
PDBsum7u50
PubMed36104361
UniProtQ71DI3|H32_HUMAN Histone H3.2 (Gene Name=H3C15)

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