Structure of PDB 7u1a Chain A Binding Site BS01

Receptor Information

>7u1a Chain A (length=617) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SFPEGKPNCLLGLTIVFTGVLPTLERGASEALAKRYGARVTKSISSKTSV
VVLGDEAGPKKLEKIKQLKIKAIDEEGFKQLIAGMPAEGGEAAEKARRKL
EEQHNIATKEAELLVKKEEERSKKLAATVVREEDKLWTVKYAPTNLQQVC
GNKGSVMKLKNWLANWENSKKNSFKHAGKDGSGVFRAAMLYGPPGIGKTT
AAHLVAQELGYDILEQNASDVRSKTLLNAGVKNALDNMSVVGYFKHNEEA
QNLNGKHFVIIMDEVDGMSGGDRGGVGQLAQFCRKTSTPLILICNERNLP
KMRPFDRVCLDIQFRRPDANSIKSRLMTIAIREKFKLDPNVIDRLIQTTR
GDIRQVINLLSTISTTTKTINHENINEISKAWEKNIALKPFDIAHKMLDG
QIYSDIGSRNFTLNDKIALYFDDFDFTPLMIQENYLSTRPSVLKPGQSHL
EAVAEAANCISLGDIVEKKIRSSEQLWSLLPLHAVLSSVYPASKVAGHMA
GRINFTAWLGQNSKSAKYYRLLQEIHYHTRLGTSTDKIGLRLDYLPTFRK
RLLDPFLKQGADAISSVIEVMDDYYLTKEDWDSIMEFFVGPDVTTAIIKK
IPATVKSGFTRKYNSMT

Ligand information

>7u1a Chain I (length=15) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gcggcattcaaggac

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7u1a A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA.
Resolution	3.3 Å
Binding residue (original residue number in PDB)	R434 F585 W638
Binding residue (residue number reindexed from 1)	R273 F424 W477

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003689	DNA clamp loader activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATP hydrolysis activity

	Biological Process
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006261	DNA-templated DNA replication
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006272	leading strand elongation
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0051301	cell division

	Cellular Component
GO:0005634	nucleus
GO:0005663	DNA replication factor C complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7u1a, PDBe:7u1a, PDBj:7u1a
PDBsum	7u1a
PubMed	35731107
UniProt	P38630\|RFC1_YEAST Replication factor C subunit 1 (Gene Name=RFC1)

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