Structure of PDB 7tz2 Chain A Binding Site BS01

Receptor Information
>7tz2 Chain A (length=220) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKRQYADCSEIFNDGYKLSGFYKIKPLQSPAEFSVYCDMSDGGGWTVIQR
RSDGSENFNRGWKDYENGFGNFVQKHGEYWLGNKNLHFLTTQEDYTLKID
LADFEKNSRYAQYKNFKVGDEKNFYELNIGEYSGTAGDSLAGSHQRMKFS
TWDRDHDNYEGNCAEEDQSGWWFNRCHSANLNGVYYSGPYTAKTDNGIVW
YTWHGWWYSLKSVVMKIRPN
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7tz2 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7tz2 LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition.
Resolution2.55 Å
Binding residue
(original residue number in PDB)		D240 D242 Y244 E245 G246
Binding residue
(residue number reindexed from 1)		D155 D157 Y159 E160 G161
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0007596 blood coagulation

View graph for
Biological Process
External links
PDB RCSB:7tz2, PDBe:7tz2, PDBj:7tz2
PDBsum7tz2
PubMed35761082
UniProtQ08830|FGL1_HUMAN Fibrinogen-like protein 1 (Gene Name=FGL1)

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