Structure of PDB 7ttw Chain A Binding Site BS01

Receptor Information

>7ttw Chain A (length=113) Species: 1280 (Staphylococcus aureus)

NHKLIEAVTKSQLRTDLPSFRPGDTLRVHVRIIEGTRERIQVFEGVVIKR
RGGGVSETFTVRKISSGVGVERTFPLHTPKIEKIEVKRRGKVRRAKLYYL
RSLRGKAARIQEI

Ligand information

>7ttw Chain 1 (length=2690)

uaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaa
ggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugau
ccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucg
auaugugaauacauagcauaucagaaggcacacccggagaacugaaacau
cuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcg
agcgaaacgggaagagcccaaaccaacguugggguuguaggacacucuag
uuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaag
guaauaauccuguagucgaaaauguugucucucuugaguggauccugagu
acgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaa
ggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaag
gugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcu
uacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaau
gaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagcc
guagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccg
aaaccaggugaucuacccuuggucagguugaaguucagguaacacugaau
ggaggaccgaaccgacuuacguugaaaagugagcggaugaacugagggua
gcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauag
cuuuagggcuagccucaagugaugauuauuggagguagagcacuguuugg
acuucagacaaacuccgaaugccaauuaauuuaacuugggagucagaaca
ugggugauaagguccguguucgaaagggaaacagcccagaccaccagcua
aggucccaaaauauauguuaaguggaaaaggauguggcguugccacagag
ugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcugug
gauuguccuuuggacaaugguaggagagcguucuaagggcguugaagcau
gaucguaaggacauguggagcgcuuagaagugagaaugccggugugagua
gcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagag
gaaggcucguccgcucuggguuagucggguccuaagcugaggccgacagg
cguaggcgauggauaacagguugauauuccuguaccaccuauaaucguau
cgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgu
cuaagcaguaaggcugccgguagcugagcugugauggggagaagaccuuc
gagucguugauuucacacugccgagaaaagccucuagauagaaaauaggu
gcccguaccgcaaaccgacacagguagucaagaugagaauucuaagguga
gcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgg
gagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauag
gcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggu
gauguauaggggcugacgccugcccggugcuggaagguuaagaggagugg
uuagcuucugcgaagcuacgaaucgaagccccaguaaacggcggccguaa
cuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccc
gcacgaaaggcguaacgauuugggcacugucucaacgagagacucgguga
aaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagac
cccguggagcuuuacuguagccugauauugaaauucggcuuucuaacccg
caccacuuaucguggugggagacagugucaggcgggcaguuugacugggg
cggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaug
guuggaaaucauucauagaguguaaaggcauaagggagcuugacugcgag
accuacaagucgagcagggucgaaagacggacuuagugauccggugguuc
cgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaaca
ggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucga
ugucggcucaucgcauccuggggcuguagucggucccaaggguugggcug
uucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacag
uucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuu
aguacgagaggaccgggauggacauaccucugguguaccaguugucgugc
caacggcauagcuggguagcuauguguggacgggauaagugcugaaagca
ucuaagcaugaagccccccucaagaugagauuucccaacuucgguuauaa
gaucccucaaagaugaugagguuaauagguucgagguggaagcaugguga
cauguggagcugacgaauacuaaucgaucgaagacuuaau

<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......
<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>
>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<
<<<<<<.........>>>>>>>.>>.>>....<<<<<......<......
>.......>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<..>>>>......<<<<<<......
........<..<<<<<<.<<<...<<<<<......>>>>>((......<<
<.....))>>>...>>>...>>>>>>...>........>>..>>>>....
.<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..
)))......]].>>>>>>>.]]...............<<....>>....]
].........<<<<....>>>>..................>>>>>>>>>>
>.......<<<<..<<<<......>>>>..>>>>...<.<........>.
>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>
...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<
...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>
.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>.
..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<
<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<
<.>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<
<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<..
.<<<(((.....<<<<<<...........<<..<<<<.<.<<........
>>.>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>
><<<<<<.....>>>>>>....>>>>>><.<<<<<<<.<<......<<<<
<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......
<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<
...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>
>...>>>...>>...<<<<<........>>>>>))<<<<<<<.......<
<...<<<<....<<<<...<<...<....<.<<<.........>>>.>.<
....<<<<...<<<........>>>...>>>>.....>.....<....>.
.......>....>>...>>>>.........>>>>..>>......>>>>>>
>>>>>..>>.....<<......>>>>>>>.<<<.......>>>..>>>>.
.<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>
.....>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............
<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>
.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<
<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<..
.....>>>>>>........<...........<<<<<<.....>>>>>>..
...>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>..
...>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......
<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<.<..>.>>>>....<<.
<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<....
.>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<
<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<
<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.(
(..>>>>..))>>>>>>>.............>>>>..]]>>>>.......
<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.....
..<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<..
...>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>
>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.
..............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<...
...>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<.......
....>>>>>...>>>>.>>>>.......>>>>>>>.<<<....>>>....
<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....
>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ttw A Structurally Characterized Staphylococcus aureus Evolutionary Escape Route from Treatment with the Antibiotic Linezolid.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): N3 R23 R53 G54 S58 R95 R96 A97 K98 Y100
• Binding residue (residue number reindexed from 1): N1 R21 R51 G52 S56 R93 R94 A95 K96 Y98

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7ttw, PDBe:7ttw, PDBj:7ttw
• PDBsum: 7ttw
• PubMed: 35736238
• UniProt: Q2FZ42|RL19_STAA8 Large ribosomal subunit protein bL19 (Gene Name=rplS)