Structure of PDB 7tr7 Chain A Binding Site BS01

Receptor Information
>7tr7 Chain A (length=276) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDIL
CLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQAPLKV
SYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAF
RKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGE
LLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLL
PALCDSKIRSKALGSDHCPITLYLAL
Ligand information
Receptor-Ligand Complex Structure
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PDB7tr7 Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		E96 Y171 N174 R177 D210 N212 N226 N229 F266 M270 M271 K276 V278 W280 H309
Binding residue
(residue number reindexed from 1)		E54 Y129 N132 R135 D168 N170 N184 N187 F224 M228 M229 K234 V236 W238 H267
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
3.1.21.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:7tr7, PDBe:7tr7, PDBj:7tr7
PDBsum7tr7
PubMed37264933
UniProtP27695|APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 (Gene Name=APEX1)

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