Structure of PDB 7tl8 Chain A Binding Site BS01

Receptor Information
>7tl8 Chain A (length=488) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAKKPTALIILDGFANRESEHGNAVKLANKPNFDRYYNKYPTTQIEASGL
DVGLPEGQMGNSEVGHMNIGAGRIVYQSLTRINKSIEDGDFFENDVLNNA
IAHVNSHDLHIFGLLSDGGVHSHYKHLFALLELAKKQGVEKVYVHAFLDG
RDVDQKSALKYIEETEAKFNELGIGQFASVSGRYYAMDRDKRWEREEKAY
NAINFDAPTYATAKEGVEASYNEGLTDEFVVPFIVENQNDGVVIFYNFRP
DRAAQLSEIFANQVKDLFYATFTKYNDNIDAAIVFEKVDLNNTIGEIAQN
NNLTQLRIAETEKYPHVTYFMSGGRNEEFKGERRRLIDSPKVATYDLKPE
MSAYEVKDALLEELNKGDLDLIILNFANPDMVGHSGMLEPTIKAIEAVDE
CLGEVVDKILDMDGYAIITADHGNSDQVLTDDDQPMTTHTTNPVPVIVTK
EGVTLRETGRLGDLAPTLLDLLNVEQPEDMTGESLIKH
Ligand information
>7tl8 Chain B (length=14) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
YQVTVWWASPWEDC
Receptor-Ligand Complex Structure
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PDB7tl8 Serum-Stable and Selective Backbone-N-Methylated Cyclic Peptides That Inhibit Prokaryotic Glycolytic Mutases.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		N61 E63 V64 M67 Q77 S78 V122 H123 R191 R257 R260 T290 P332 F337
Binding residue
(residue number reindexed from 1)		N61 E63 V64 M67 Q77 S78 V120 H121 R189 R249 R252 T273 P315 F320
Enzymatic activity
Enzyme Commision number 5.4.2.12: phosphoglycerate mutase (2,3-diphosphoglycerate-independent).
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004619 phosphoglycerate mutase activity
GO:0016853 isomerase activity
GO:0030145 manganese ion binding
GO:0046537 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
GO:0046872 metal ion binding
Biological Process
GO:0006007 glucose catabolic process
GO:0006096 glycolytic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tl8, PDBe:7tl8, PDBj:7tl8
PDBsum7tl8
PubMed35904259
UniProtQ5HHP2|GPMI_STAAC 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (Gene Name=gpmI)

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