Structure of PDB 7tkt Chain A Binding Site BS01

Receptor Information
>7tkt Chain A (length=390) Species: 869211 (Spirochaeta thermophila DSM 6578) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIP
LDLSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRIL
SYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYW
TITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLD
AAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVL
KELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGE
YIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAP
RTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAV
Ligand information
Ligand IDCMP
InChIInChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
InChIKeyIVOMOUWHDPKRLL-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C4C(O3)COP(=O)(O4)O)O)N
ACDLabs 10.04O=P3(OCC4OC(n1c2ncnc(N)c2nc1)C(O)C4O3)O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@H]4[C@H](O3)CO[P@](=O)(O4)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH]4CO[P](O)(=O)O[CH]4[CH]3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4CO[P@](O)(=O)O[C@H]4[C@H]3O
FormulaC10 H12 N5 O6 P
NameADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE;
CYCLIC AMP;
CAMP
ChEMBLCHEMBL316966
DrugBankDB02527
ZINCZINC000003873977
PDB chain7tkt Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7tkt Anionic lipids unlock the gates of select ion channels in the pacemaker family.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		F366 G367 E368 M369 R377 T378 A379
Binding residue
(residue number reindexed from 1)		F340 G341 E342 M343 R351 T352 A353
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity
GO:0044877 protein-containing complex binding
Biological Process
GO:0034220 monoatomic ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tkt, PDBe:7tkt, PDBj:7tkt
PDBsum7tkt
PubMed36352139
UniProtG0GA88

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