Structure of PDB 7t92 Chain A Binding Site BS01

Receptor Information

>7t92 Chain A (length=298) Species: 573729 (Thermothelomyces thermophilus ATCC 42464)

TRPAFRVGQVDAELLDEELVELLRGQVREALRYVGGGGSGVAQDWEAEIS
LALRAVLFKLTVWDHDATYGAALQNLKYTDARRDGPALAPPSRWQKALYG
LVTVGGRYLWAKWEDWLLEQDDPSPRVKRLARWTSSLSTLHASAALVSFL
VFLLHGRYRTLLDRLLRMRLAPPTSQVSFEYLNRQLVWHAFTEFLLFVLP
LVGINRWRRWLARTWRDKKGEYSFLPERTCAICYRDQNSVVGSAQTDITN
PYEAIPCGCTYCFVCLATRIEREEGEGWPCLRCGELIKECKPWNGDVL

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7t92 Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7t92 A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): C311 C334
• Binding residue (residue number reindexed from 1): C257 C280
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 2.3.2.36: RING-type E3 ubiquitin transferase (cysteine targeting).

Gene Ontology

Molecular Function

• GO:0008270 zinc ion binding

Biological Process

• GO:0007031 peroxisome organization
• GO:0016558 protein import into peroxisome matrix

Cellular Component

• GO:0005778 peroxisomal membrane

External links

• PDB: RCSB:7t92, PDBe:7t92, PDBj:7t92
• PDBsum: 7t92
• PubMed: 35768507
• UniProt: G2Q1C9|PEX2_THET4 Peroxisome assembly protein 2 (Gene Name=PEX2)