Structure of PDB 7t8d Chain A Binding Site BS01

Receptor Information

>7t8d Chain A (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGT
DVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRT
VIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYS
TDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYT
SADATINFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLN
MVTYDIKLS

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

7t8d Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7t8d Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability.
Resolution	1.38 Å
Binding residue (original residue number in PDB)	D380 N428 A429 I477 D478
Binding residue (residue number reindexed from 1)	D137 N185 A186 I234 D235
Annotation score	4

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:7t8d, PDBe:7t8d, PDBj:7t8d
PDBsum	7t8d
PubMed	36579626
UniProt	Q99972\|MYOC_HUMAN Myocilin (Gene Name=MYOC)

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