Structure of PDB 7t7k Chain A Binding Site BS01

Receptor Information
>7t7k Chain A (length=433) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMKFLNPPFPYSMTSDPESFGHECFTRRWGIILTGIEKDVSERLSKLAST
SKDSEVVAQGKPLLNDLEAFKSDIKNDRPLVPLEGEGQDIVEYNEELKQL
DNASWGNAPWLYSECYYYRRISLIFARYSEWKAYDPFFQQKDSTLKSSRA
AVEELAGRYCLLEEELNSSHIAYMVFVEMAQISLWGNATDLSLLTNLSYE
ELQNLQGQKVVEESQKNILVNDFPTVWSKLKDVHNGRIDFVLDNAGFELY
VDLIFAAYLLKAGIAKEIVLHPKDFPWFVSDVLPYDIEYLLTNLDTIFPT
ESVTKFATDLRSFSAKGQLRLRTDPFWTTAHYFGRMPDFAAGLLTELEKS
DMIFFKGDLNYRKLTGDCLWPRTTPFGKTLGPIANAINACALRTCKADVV
VGLPDGLYEKIAKDLPHWERTGKYAVVEFCPKA
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain7t7k Chain A Residue 507 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7t7k Fission yeast Duf89 and Duf8901 are cobalt/nickel-dependent phosphatase-pyrophosphatases that act via a covalent aspartyl-phosphate intermediate.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		S71 K74 N75
Binding residue
(residue number reindexed from 1)		S72 K75 N76
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.-
Gene Ontology
Molecular Function
GO:0004427 inorganic diphosphate phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0046872 metal ion binding
GO:0097023 fructose 6-phosphate aldolase activity
GO:0103026 fructose-1-phosphatase activity
Biological Process
GO:0006974 DNA damage response
GO:0030643 intracellular phosphate ion homeostasis
GO:1990748 cellular detoxification
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7t7k, PDBe:7t7k, PDBj:7t7k
PDBsum7t7k
PubMed35314193
UniProtQ9UT55|ART1A_SCHPO Damage-control phosphatase SPAC806.04c (Gene Name=SPAC806.04c)

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