Structure of PDB 7t3n Chain A Binding Site BS01

Receptor Information
>7t3n Chain A (length=452) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGG
KVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAA
ILLTSTLNMLIPSAARVHYGCVIFVQILQGLVQGVTYPACHGIWSKWAPP
LERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYM
FWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFT
SMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLV
MTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHT
RGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGM
VCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYALFASGEKQPWADP
EE
Ligand information
Ligand IDC5B
InChIInChI=1S/C7H11NO4/c8-7(6(11)12)2-1-4(3-7)5(9)10/h4H,1-3,8H2,(H,9,10)(H,11,12)/t4-,7+/m1/s1
InChIKeyYFYNOWXBIBKGHB-FBCQKBJTSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1CC(CC1C(=O)O)(C(=O)O)N
OpenEye OEToolkits 1.5.0C1C[C@](C[C@@H]1C(=O)O)(C(=O)O)N
CACTVS 3.341N[C]1(CC[CH](C1)C(O)=O)C(O)=O
ACDLabs 10.04O=C(O)C1(N)CC(C(=O)O)CC1
CACTVS 3.341N[C@]1(CC[C@H](C1)C(O)=O)C(O)=O
FormulaC7 H11 N O4
Name(1S,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID;
1S,3R-ACPD
ChEMBLCHEMBL34453
DrugBank
ZINCZINC000002004213
PDB chain7t3n Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7t3n Substrate Recognition, Directional Flux, and Allostery in a Synaptic Vesicle Glutamate Transporter
Resolution3.0 Å
Binding residue
(original residue number in PDB)		Y135 Y195 Y223 R322 F326 Y327
Binding residue
(residue number reindexed from 1)		Y77 Y137 Y165 R264 F268 Y269
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005254 chloride channel activity
GO:0005313 L-glutamate transmembrane transporter activity
GO:0005326 neurotransmitter transmembrane transporter activity
GO:0005436 sodium:phosphate symporter activity
GO:0015293 symporter activity
GO:0015297 antiporter activity
GO:0015386 potassium:proton antiporter activity
GO:0022857 transmembrane transporter activity
GO:0140787 phosphate ion uniporter activity
GO:0140788 L-glutamate uniporter activity
Biological Process
GO:0001504 neurotransmitter uptake
GO:0003407 neural retina development
GO:0006814 sodium ion transport
GO:0006817 phosphate ion transport
GO:0006820 monoatomic anion transport
GO:0006821 chloride transport
GO:0006836 neurotransmitter transport
GO:0015813 L-glutamate transmembrane transport
GO:0021766 hippocampus development
GO:0034220 monoatomic ion transmembrane transport
GO:0035249 synaptic transmission, glutamatergic
GO:0035725 sodium ion transmembrane transport
GO:0044341 sodium-dependent phosphate transport
GO:0050803 regulation of synapse structure or activity
GO:0051938 L-glutamate import
GO:0055062 phosphate ion homeostasis
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
GO:0098700 neurotransmitter loading into synaptic vesicle
GO:1902476 chloride transmembrane transport
GO:1902600 proton transmembrane transport
GO:1990384 hyaloid vascular plexus regression
Cellular Component
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0030672 synaptic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0034707 chloride channel complex
GO:0043005 neuron projection
GO:0045202 synapse
GO:0060076 excitatory synapse
GO:0098793 presynapse
GO:1990030 pericellular basket

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7t3n, PDBe:7t3n, PDBj:7t3n
PDBsum7t3n
PubMed
UniProtQ9JI12|VGLU2_RAT Vesicular glutamate transporter 2 (Gene Name=Slc17a6)

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