Structure of PDB 7sxh Chain A Binding Site BS01

Receptor Information
>7sxh Chain A (length=341) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK
VLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSKDEVYLNLVLDYVPETV
YRVARHYSRQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDP
DTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVW
SAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYEFK
FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE
LRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7sxh Elucidation of the GSK3 alpha Structure Informs the Design of Novel, Paralog-Selective Inhibitors.
Resolution2.09 Å
Binding residue
(original residue number in PDB)		I228 V263 L266 V267 F291 F293 P294
Binding residue
(residue number reindexed from 1)		I187 V222 L225 V226 F249 F251 P252
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7sxh, PDBe:7sxh, PDBj:7sxh
PDBsum7sxh
PubMed36812145
UniProtP49841|GSK3B_HUMAN Glycogen synthase kinase-3 beta (Gene Name=GSK3B)

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