Structure of PDB 7sxg Chain A Binding Site BS01

Receptor Information
>7sxg Chain A (length=334) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVATLGQPEREVAYTDIKVIGNGSFGVVYQARLRELVAIKKVLQDKRFKN
RELQIMRKLDHCNIVRLRYFFYSSGEELYLNLVLEYVPETVYRVARHFTK
AKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKL
CDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLA
ELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKA
HPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGT
QLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7sxg Elucidation of the GSK3 alpha Structure Informs the Design of Novel, Paralog-Selective Inhibitors.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		V330 I333 Y351 F354 F356 P357
Binding residue
(residue number reindexed from 1)		V219 I222 Y240 F243 F245 P246
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7sxg, PDBe:7sxg, PDBj:7sxg
PDBsum7sxg
PubMed36812145
UniProtP49840|GSK3A_HUMAN Glycogen synthase kinase-3 alpha (Gene Name=GSK3A)

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