Structure of PDB 7sxe Chain A Binding Site BS01

Receptor Information
>7sxe Chain A (length=638) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVE
TLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLALGVGDGVLLKAVAQ
ATGRQLESVRAEAAEKGDVGLVAENSRMLPPPPLTASGVFSKFRDIARLT
GSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQ
AVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDR
IIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTC
EYKYDGQRAQIHALEGGEVKIFSRNQADNTGKYPDIISRIPKIKLPSVTS
FILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYL
NGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSV
KDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAY
LGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKAL
VLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSD
KGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQI
Ligand information
Receptor-Ligand Complex Structure
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PDB7sxe Structures of LIG1 that engage with mutagenic mismatches inserted by pol beta in base excision repair.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		L347 G348 G350 Q572 R573 S588 F635 F872
Binding residue
(residue number reindexed from 1)		L87 G88 G90 Q307 R308 S323 F370 F607
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7sxe, PDBe:7sxe, PDBj:7sxe
PDBsum7sxe
PubMed35790757
UniProtP18858|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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