BioLiP

Receptor Information

>7sum Chain A (length=645) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVET
LSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLALGVGDGVLLKAVAQA
TGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDI
ARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLA
ALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVP
DLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEA
AFTCEYKYDGQRAQIHALEGGEVKIFSRNQADNTGKYPDIISRIPKIKLP
SVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFD
LIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFL
EQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVV
IGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQS
LKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGL
VDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQ

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	7sum Structures of LIG1 that engage with mutagenic mismatches inserted by pol beta in base excision repair.
Resolution	2.9 Å
Binding residue (original residue number in PDB)	G348 G350 Q572 S588 R589 N590 F635 R643 F872
Binding residue (residue number reindexed from 1)	G87 G89 Q311 S327 R328 N329 F374 R382 F611

Enzyme Commision number

6.5.1.1: DNA ligase (ATP).

	Molecular Function
GO:0003677	DNA binding
GO:0003909	DNA ligase activity
GO:0003910	DNA ligase (ATP) activity
GO:0005524	ATP binding

	Biological Process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0071897	DNA biosynthetic process

PDB	RCSB:7sum, PDBe:7sum, PDBj:7sum
PDBsum	7sum
PubMed	35790757
UniProt	P18858\|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

[Back to BioLiP]

Structure of PDB 7sum Chain A Binding Site BS01