Structure of PDB 7st9 Chain A Binding Site BS01

Receptor Information

>7st9 Chain A (length=522) Species: 559292 (Saccharomyces cerevisiae S288C)

GEQWYEKFKPNCLEQVAIHKRKLKDVQEALDAMFLPNAKHRILLLSGPSG
CSKSTVIKELSKILVPKYRQNSNGTSFRSTPNEHKVTEFRGDCIVNDLPQ
MESFSEFLKGARYLVMSNLSLILIEDLPNVFHIDTRRRFQQLILQWLYSS
EPLLPPLVICITECEIPENDNNYRKFGIDYTFSAETIMNKEILMHPRLKR
IKFNPINSTLLKKHLKFICVQNMKMLKEKNKWNKRQEVIDYIAQETGDIR
SAITTLQFWATSSGSLPISTRESTISYFHAIGKVIHGSHSTNNDNEMINN
LFENSNNLLSKEDFKLGILENYNTFNKGEFSISDASSIVDCLSECDNMNG
LPESNEYGLREVRKTFRNISKQGHNHGTVYFPREWKVRKLQNSFKVQAED
WLNVSLYKYNAVHSFRNITLEFGYYAPLIRKCQSYKKKYILYYLKNLDKF
SDIMKVENGIDVVDRIGGPIEALSDHLEDQKKERDRRLRMLIDQYERNVM
MANDDLEDEETSFNDDPIVDSD

Ligand information

>7st9 Chain J (length=25)

ggaaggagcgttttttttttttttt

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7st9 Mechanisms of loading and release of the 9-1-1 checkpoint clamp.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): H81 R83 K84 P161 Q162 M163 N191 H194 N233 F238 E247 N269 S270 T271 F340 V441 Y442 F443 W447
• Binding residue (residue number reindexed from 1): H19 R21 K22 P99 Q100 M101 N129 H132 N171 F176 E185 N207 S208 T209 F278 V379 Y380 F381 W385

Gene Ontology

Molecular Function

• GO:0003682 chromatin binding
• GO:0003689 DNA clamp loader activity
• GO:0005515 protein binding
• GO:0005524 ATP binding

Biological Process

• GO:0000077 DNA damage checkpoint signaling
• GO:0006281 DNA repair
• GO:0006289 nucleotide-excision repair
• GO:0006974 DNA damage response
• GO:0007131 reciprocal meiotic recombination
• GO:0033314 mitotic DNA replication checkpoint signaling

Cellular Component

• GO:0005634 nucleus
• GO:0031389 Rad17 RFC-like complex

External links

• PDB: RCSB:7st9, PDBe:7st9, PDBj:7st9
• PDBsum: 7st9
• PubMed: 35314831
• UniProt: P32641|RAD24_YEAST Checkpoint protein RAD24 (Gene Name=RAD24)