Structure of PDB 7ssy Chain A Binding Site BS01

Receptor Information
>7ssy Chain A (length=346) Species: 6100,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRN
RPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEG
FLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFC
LETLPEFRDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIV
AIIPYFITLGTELALAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM
RELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTV
GYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET
Ligand information
Ligand IDK
InChIInChI=1S/K/q+1
InChIKeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[K+]
FormulaK
NamePOTASSIUM ION
ChEMBLCHEMBL1233793
DrugBankDB01345
ZINC
PDB chain7ssy Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ssy Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators.
Resolution2.89 Å
Binding residue
(original residue number in PDB)		G446 G448
Binding residue
(residue number reindexed from 1)		G301 G303
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005216 monoatomic ion channel activity
GO:0005244 voltage-gated monoatomic ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0015271 outward rectifier potassium channel activity
Biological Process
GO:0001508 action potential
GO:0006091 generation of precursor metabolites and energy
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0008218 bioluminescence
GO:0021554 optic nerve development
GO:0022038 corpus callosum development
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0030424 axon
GO:0034702 monoatomic ion channel complex
GO:0042734 presynaptic membrane
GO:0044305 calyx of Held
GO:0045121 membrane raft
GO:0045211 postsynaptic membrane
GO:0048471 perinuclear region of cytoplasm
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ssy, PDBe:7ssy, PDBj:7ssy
PDBsum7ssy
PubMed35788586
UniProtP22001|KCNA3_HUMAN Potassium voltage-gated channel subfamily A member 3 (Gene Name=KCNA3);
P42212|GFP_AEQVI Green fluorescent protein (Gene Name=GFP)

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