Structure of PDB 7sqa Chain A Binding Site BS01

Receptor Information

>7sqa Chain A (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DKMQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVI
YDMNSLMMGEDKIKFKHIQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKS
IPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREF
LKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLN
VKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTET

Ligand information

>7sqa Chain D (length=12) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

MGLEAIIRKALM

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	7sqa PPAR gamma Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles.
Resolution	2.499 Å
Binding residue (original residue number in PDB)	V293 T297 K301 V315 L318
Binding residue (residue number reindexed from 1)	V91 T95 K99 V113 L116

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7sqa, PDBe:7sqa, PDBj:7sqa
PDBsum	7sqa
PubMed	37146157
UniProt	P37231\|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

[Back to BioLiP]