Structure of PDB 7spz Chain A Binding Site BS01

Receptor Information

>7spz Chain A (length=328) Species: 184922 (Giardia lamblia ATCC 50803)

ATYMLPSLHDILDQHTYKWIFFGGKGGVGKTTTSSSFSVLMAETRPNEKF
LLLSTDPAHNISDAFDQKFGKAPTQVSGIPNLYAMEVDDNDAESKSEGDM
FGGLNDLITCASSFIKDGTFPGMDEMWSFINLIKLINEYSTVIFDTAPTG
HTLRFLELPETVNKVLEIFTRLKDNMGGMLSMVMQTMGLSQNDIFGLIDK
TYPKIDVVKRISAEFRDPSLCTFVGVCIPEFLSLYETERLVQRLAVLDMD
CHAIVINFVLDANAATPCSMCRSRARMQNKYIDQINELYDDFNIVLSPLR
HDEVRGIANLRDYAETLIKPYRFCWSAN

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7spz Chain A Residue 400

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7spz Structurally derived universal mechanism for the catalytic cycle of the tail-anchored targeting factor Get3.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): C287 C290
• Binding residue (residue number reindexed from 1): C268 C271
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.-.-

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity
• GO:0046872 metal ion binding

Biological Process

• GO:0045048 protein insertion into ER membrane

Cellular Component

• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum

External links

• PDB: RCSB:7spz, PDBe:7spz, PDBj:7spz
• PDBsum: 7spz
• PubMed: 35851188
• UniProt: A8B3G9|ASNA_GIAIC ATPase ASNA1 homolog (Gene Name=GL50803_7953)