BioLiP

Receptor Information

>7sol Chain A (length=1011) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVT
IHDTEKCQAWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSS
VPFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCRSQCPPIKFISADVH
GIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLENHPHKL
ETGQFLTFREINGMTGLNGSIQQITVISPFSFSIGDTTELEPYLHGGIAV
QVKTPKTVFFESLERQLKHPKCLIVDFSNPEAPLEIHTAMLALDQFQEKY
SRKPNVGCQQDSEELLKLATSISETLEEKPDVNADIVHWLSWTAQGFLSP
LAAAVGGVASQEVLKAVTGKFSPLCQWLYLEAADIVESLGKPECEEFLPR
GDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKE
KGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKID
AHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLANLRPLL
DSGTMGTKGHTEVIVPHLTESYNSHRDPPEEEIPFATLKSFPAAIEHTIQ
WARDKFESSFSHKPSLFNKFWQTYSSAEEVLQKIQSGHSLEGCFQVIKLL
SRRPRNWSQCVELARLKFEKYFNHKALQLLHCFPLDIRLKDGSLFWQSPK
RPPSPIKFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSADALLNILSE
VKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILSNEATK
SDLQMAVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGK
IIPAIATTTATVSGLVALEMIKVTGGYPFEAYKNCFLNLAIPIVVFTETT
EVRKTKIRNGISFTIWDRWTVHGKEDFTLLDFINAVKEKYGIEPTMVVQG
VKMLYVPVMPGHAKRLKLTMHKLVKPTTEKKYVDLTVSFAPDIDGDEDLP
GPPVRYYFSHD

Ligand ID

IHP

InChI

InChI=1S/C6H18O24P6/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24)/t1-,2-,3-,4+,5-,6-

InChIKey

IMQLKJBTEOYOSI-GPIVLXJGSA-N

SMILES

Software	SMILES
CACTVS 3.385	O[P](O)(=O)O[CH]1[CH](O[P](O)(O)=O)[CH](O[P](O)(O)=O)[CH](O[P](O)(O)=O)[CH](O[P](O)(O)=O)[CH]1O[P](O)(O)=O
ACDLabs 12.01 OpenEye OEToolkits 2.0.7	C1(C(C(C(C(C1OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O
CACTVS 3.385	O[P](O)(=O)O[C@@H]1[C@H](O[P](O)(O)=O)[C@H](O[P](O)(O)=O)[C@@H](O[P](O)(O)=O)[C@H](O[P](O)(O)=O)[C@H]1O[P](O)(O)=O

Formula

C6 H18 O24 P6

Name

INOSITOL HEXAKISPHOSPHATE;
MYO-INOSITOL HEXAKISPHOSPHATE;
INOSITOL 1,2,3,4,5,6-HEXAKISPHOSPHATE

PDB chain

7sol Chain A Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	7sol Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6.
Resolution	2.25001 Å
Binding residue (original residue number in PDB)	K628 K644 S647 K652 K687 R691 K706 K709 Y710 K714 K800
Binding residue (residue number reindexed from 1)	K589 K605 S608 K613 K648 R652 K667 K670 Y671 K675 K761
Annotation score	1

Enzyme Commision number

6.2.1.45: E1 ubiquitin-activating enzyme.

	Molecular Function
GO:0004792	thiosulfate sulfurtransferase activity
GO:0004839	ubiquitin activating enzyme activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008641	ubiquitin-like modifier activating enzyme activity
GO:0016779	nucleotidyltransferase activity
GO:0016874	ligase activity
GO:0019780	FAT10 activating enzyme activity

	Biological Process
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007612	learning
GO:0007626	locomotory behavior
GO:0016567	protein ubiquitination
GO:0021764	amygdala development
GO:0021766	hippocampus development
GO:0032446	protein modification by small protein conjugation
GO:0036211	protein modification process
GO:0060996	dendritic spine development

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

PDB	RCSB:7sol, PDBe:7sol, PDBj:7sol
PDBsum	7sol
PubMed	35986001
UniProt	A0AVT1\|UBA6_HUMAN Ubiquitin-like modifier-activating enzyme 6 (Gene Name=UBA6)

[Back to BioLiP]

Structure of PDB 7sol Chain A Binding Site BS01