Structure of PDB 7sn6 Chain A Binding Site BS01

Receptor Information
>7sn6 Chain A (length=104) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGSTEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPV
DGVEVPGCGKIFVEFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSYHR
RDFW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7sn6 A UHM-ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		M383 E397 D401 E405 L449 G451 R452 K453 F454
Binding residue
(residue number reindexed from 1)		M12 E26 D30 E34 L78 G80 R81 K82 F83
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:7sn6, PDBe:7sn6, PDBj:7sn6
PDBsum7sn6
PubMed35780835
UniProtP26368|U2AF2_HUMAN Splicing factor U2AF 65 kDa subunit (Gene Name=U2AF2)

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