Structure of PDB 7smc Chain A Binding Site BS01

Receptor Information
>7smc Chain A (length=340) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFTQSVSRLQSIVAGLKNAPSDQLINIFESCVRNPVENIMKILKGIGETF
CQHYTQSTDEQPGSHIDFAVNRLKLAEILYYKILETVMVQETRRLHGMDM
SVLLEQDIFHRSLMACCLEIVLFAYSSPRTFPWIIEVLNLQPFYFYKVIE
VVIRSEEGLSRDMVKHLNSIEEQILESLAWSHDSALWEALQVSANKVPTC
EEVIFTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFTLV
HCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVY
RSVLLKSEERGDLIKFYNTIYVGRVKSFALKYDPLSPFPH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7smc Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		Y849 F861 Q862 K866 R880 I931 Y934 N935
Binding residue
(residue number reindexed from 1)		Y270 F282 Q283 K287 R301 I314 Y317 N318
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:7smc, PDBe:7smc, PDBj:7smc
PDBsum7smc
PubMed35716663
UniProtP28749|RBL1_HUMAN Retinoblastoma-like protein 1 (Gene Name=RBL1)

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