Structure of PDB 7slp Chain A Binding Site BS01

Receptor Information
>7slp Chain A (length=239) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QYGNYCKYYGYRNPSCEDGRLRVLKPEWFRGRDVLDLGCNVGHLTLSIAC
KWGPSRMVGLDIDSRLIHSARQNIRHYLSEEKRSCFPASLTASRGPIAAP
QVPLDGADTSVFPNNVVFVTGNYVLDRDDLVEAQTPEYDVVLCLSLTKWV
HLNWGDEGLKRMFRRIYRHLRPGGILVLEPQPWSSYGKRKTLTETIYKNY
YRIQLKPEQFSSYLTSPDVGFSSYELVARPVYLFHKARS
Ligand information
>7slp Chain R (length=37) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaaugaggcgcugcauguggcagucugccuuucuuuu
.....<<<<<<<<<.....>>>>>..>>>>.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7slp Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		Y418 C419 R478 S530 R531 R626
Binding residue
(residue number reindexed from 1)		Y5 C6 R65 S93 R94 R189
Enzymatic activity
Enzyme Commision number 2.1.1.-
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7slp, PDBe:7slp, PDBj:7slp
PDBsum7slp
PubMed35320752
UniProtQ7L2J0|MEPCE_HUMAN 7SK snRNA methylphosphate capping enzyme (Gene Name=MEPCE)

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