Structure of PDB 7sj6 Chain A Binding Site BS01

Receptor Information

>7sj6 Chain A (length=174) Species: 10665 (Tequatrovirus T4)

TTENLYFQGSMNIFEMLRIDEGLRLKIYKDCEGYYTIGIGHLLTKSPDLN
AAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDS
LDAVRRCAAINHVFQMGVTGVAGFTNVLRMLQQKRWDEAAVNLAKSRWYN
QCPDRAKRVITTFRTGTWDAYKNL

Ligand information

• Ligand ID: B20
• InChI: InChI=1S/C4H6BN/c1-2-4-6-5-3-1/h1-6H
• InChIKey: OGZZEGWWYQKMSO-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: B1NC=CC=C1
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: B1C=CC=CN1
• Formula: C4 H6 B N
• Name: 1,2-dihydro-1,2-azaborinine;
  1,2-DIHYDRO-1,2-AZABORINE
• PDB chain: 7sj6 Chain A Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7sj6 The impact of introducing a histidine into an apolar cavity site on docking and ligand recognition.
• Resolution: 1.72 Å
• Binding residue (original residue number in PDB): A99 L118
• Binding residue (residue number reindexed from 1): A109 L128
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.2.1.17: lysozyme.

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds

Biological Process

• GO:0009253 peptidoglycan catabolic process
• GO:0016998 cell wall macromolecule catabolic process
• GO:0031640 killing of cells of another organism
• GO:0042742 defense response to bacterium
• GO:0044659 viral release from host cell by cytolysis

Cellular Component

• GO:0030430 host cell cytoplasm

External links

• PDB: RCSB:7sj6, PDBe:7sj6, PDBj:7sj6
• PDBsum: 7sj6
• UniProt: P00720|ENLYS_BPT4 Endolysin (Gene Name=E)