Structure of PDB 7siq Chain A Binding Site BS01

Receptor Information
>7siq Chain A (length=524) Species: 522373 (Stenotrophomonas maltophilia K279a) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SEVANEASRRRTFAIISHPDAGKTTLTEKLLLFGGAIQMAGSVKGRKTSD
WMALEKERGISVTSSVMQFPYEDKIVNLLDTPGHADFGEDTYRVLTAVDS
ALMVIDVAKGVEERTIKLMEVCRLRDTPIMTFINKLDREGKDPIELLDEV
ETVLGIQCAPVTWPIGMGQRLKGVVHLLTGEVHLYEPGRNFTRQDSTIFP
SIDAPGLAEKIGAQMLADLRDELELVQGASHPFDLEAYRAGKQTPVFFGS
GVNNFGVQPLLDFFVEHAPSPQARSTTGREIAPEENKLTGFVFKIQANMD
PQHRDRVAFMRVCSGRFSAGMKTFHVRTGKEMKLANALTFMASDREIAAE
AWPGDVIGIHNHGTISIGDTFTEGEAVTFTGIPNFAPELFRRARLRDPLK
LKQLQKGLAQLSEEGATQFFRPLTSNDLILGAVGVLQFDVAAYRLKDEYG
VEATFEPVSVTTARWVHCSNEKKLEEFREKNALNLALDAAGHLVYLAPTR
VNLQLAQERSPDVRFSATREAAHT
Ligand information
Ligand IDGDP
InChIInChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyQGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H15 N5 O11 P2
NameGUANOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL384759
DrugBankDB04315
ZINCZINC000008215481
PDB chain7siq Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7siq Crystal structure of a peptide chain release factor 3 (prfC) from Stenotrophomonas maltophilia bound to GDP
Resolution2.95 Å
Binding residue
(original residue number in PDB)		D21 G23 K24 T25 T26 H90 N140 K141 D143 S256 V258
Binding residue
(residue number reindexed from 1)		D20 G22 K23 T24 T25 H84 N134 K135 D137 S250 V252
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016149 translation release factor activity, codon specific
GO:0016150 translation release factor activity, codon nonspecific
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006412 translation
GO:0006415 translational termination
GO:0006449 regulation of translational termination
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7siq, PDBe:7siq, PDBj:7siq
PDBsum7siq
PubMed
UniProtB2FR00|RF3_STRMK Peptide chain release factor 3 (Gene Name=prfC)

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