Structure of PDB 7si3 Chain A Binding Site BS01

Receptor Information
>7si3 Chain A (length=872) Species: 8364 (Xenopus tropicalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APEKCFLQITGMTCISCVSNIERNLKKKDGIVSVLVALMSGKAEVKFYPD
RIEPLEIAQLVEDLGFGASVMEGNVELIITGMTCASCHNIESRLMRTPGI
LQASVALATCKAQVKFDPEIVGPRDIIRIIEGIGFQASLAHKEEIKQWRN
SFLFSLLFGIPVIILMIYMLAATMVLDRNIVPGLSIINLVFFILCTFVQT
LGGRYFYVQAYKSLKHKATNMDVLIVLATTIAYIYSVVILTVAMVEKADK
SPETFFDTPPMLFMFIALGRWLEHIAKSKTSEALAKLISLQATEAAVVTF
GANQIILREEQVAVELVQRGDIVKVVPGGKFPVDGKVIEGTSMADESLIT
GEPMPVRKKPGSMVIAGSINAHGTVLVEATHVGSETTLAQIVKLVEEAQM
SKAPIQQLADKISGYFVPFIIIISVVTLVTWIIIGFVNFDIIIKYFPSYS
KNISKTEVIIRVAFQTSITVLSIACPCALGLATPTAVMVGTGVAAQNGIL
IKGGEPLEMAHKIKAVMFDKTGTITHGVPKVMRVLLLVKMPLKRMLAVVG
TAEASSEHPLGMAVTKYCKEELGTELLGYCTDFQAVPGCGISCKVNNIES
VLVQHTVLIGNREWMRRNGLHISTDVDEAMSSHEMKGQTAVLVAIDGELC
GMIAIADTVKQEAALAVHTLKSMGIDVVLITGDNRKTAKAIATQVGIKKV
FAEVLPSHKVAKVQALQSDNKRVAMVGDGVNDSPALARADVGIAIGTGTD
VAIEAADIVLIRNDLLDVVASIHLSKRTVRRIRLNFVFALIYNLLGIPIA
AGVFMPAGLVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPDSDRYEARAQ
GHMKPLTPSQISVHIGMDDRWR
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7si3 Chain A Residue 1501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7si3 Structure of the Wilson disease copper transporter ATP7B.
Resolution3.19 Å
Binding residue
(original residue number in PDB)		D1024 T1026 D1273
Binding residue
(residue number reindexed from 1)		D519 T521 D728
Annotation score1
Enzymatic activity
Enzyme Commision number 7.2.2.8: P-type Cu(+) transporter.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005507 copper ion binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0046872 metal ion binding
GO:0140581 P-type monovalent copper transporter activity
Biological Process
GO:0006812 monoatomic cation transport
GO:0006825 copper ion transport
GO:0035434 copper ion transmembrane transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7si3, PDBe:7si3, PDBj:7si3
PDBsum7si3
PubMed35245129
UniProtA0A6I8R0A5

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