Structure of PDB 7shl Chain A Binding Site BS01

Receptor Information
>7shl Chain A (length=645) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLKPRVVDFDETWNKLLTTIKAVVMLDYVERATWNDRFSDIYALCVAYPE
PLGERLYTETKIFLENHVQQLHTRVLDSAEQVLVMYFRYWEEYSRGADYM
DCLYRYLNTQYIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDLWRKLM
IEPLQDTLLIMLLREIKRDRCGEDPNQKVIHGVINSFVHVEQYKKKFPLK
FYQEIFESPFLAETGEYYKQEASNLLQESNCSQYMEKILGRLKDEEIRCR
KYLHPSSYNKVIHECQQRMVADHLQFLHAECHNIIRQERRNDMANMYTLL
RAVSSGLPHMIQELQNHIHDEGLRAISNLSQENMPTQFVESVLEVHSKFV
QLVNCVLNGDQHFMSALDKALTCVVNYREPKSVCKAPELLAKYCDNMLKK
SAKGMTENEVEDKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSM
DSEETMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKSQDTVI
DLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYNQHFSGR
KLTWLHYLCTGEVKMNYLCKPYVAMVTTYQMAVLLAFNNSEIITYKELQD
STQMNEKELTKTIKSLLDVKMINHDSDKEDIEGESTFSLNMNFSS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7shl Structure of CRL2Lrr1, the E3 ubiquitin ligase that promotes DNA replication termination in vertebrates.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		G504 I505 S506 F507 Q508 I509 Y510 V511 L512 Q513 A514 L533 Y544 G550 R551 K552 L553 T554 L556 C560 T561 G562 E563 K565 M566 Y568 L569 M582 N589
Binding residue
(residue number reindexed from 1)		G503 I504 S505 F506 Q507 I508 Y509 V510 L511 Q512 A513 L532 Y543 G549 R550 K551 L552 T553 L555 C559 T560 G561 E562 K564 M565 Y567 L568 M581 N588
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0030674 protein-macromolecule adaptor activity
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
GO:0019005 SCF ubiquitin ligase complex
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031462 Cul2-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7shl, PDBe:7shl, PDBj:7shl
PDBsum7shl
PubMed34850944
UniProtQ6PCF2

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