Structure of PDB 7sb3 Chain A Binding Site BS01

Receptor Information
>7sb3 Chain A (length=1178) Species: 31631 (Human coronavirus OC43) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VIGDLKCPLDSRTGSLNNSISTATVDVTNGLGTYYVLDRVYLNTTLFLNG
YYPTSGSTYRNMALKGTDKLSTLWFKPPFLSDFINGIFAKVKNTKVFKDG
VMYSEFPAITIGSTFVNTSYSVVVQPRTINSLQGLLEVSVCQYNMCEYPH
TICHPKLGNHFKELWHMDVSCLYKRNFTYDVNATYLYFHFYQEGGTFYAY
FTDTGVVTKFLFNVYLGMALSHYYVMPLTCISRRDIGFTLEYWVTPLTSR
QYLLAFNQDGIIFNAVDCMSDFMSEIKCKTQSIAPPTGVYELNGYTVQPI
ADVYRRKPDLPNCNIEAWLNDKSVPSPLNWERKTFSNCNFNMSSLMSFIQ
ADSFTCNNIDAAKIYGMCFSSITIDKFAIPNGRKVDLQLGNLGYLQSFNY
RIDTTATSCQLYYNLPAANVSVSRFNPSTWNKRFGFIENSVFKPQPAGVL
TNHDVVYAQHCFKAPKNFCPCKLNSNGIGTCPAGTNYLTCHNLCNPDPIT
FTGPYKCPQTKSLVGIGEHCSGLAVKSDYCGGNPCTCQPQAFLGWSADSC
LQGDKCNIFANLILHDVNSGLTCSTDLQKANTDIKLGVCVNYDLYGISGQ
GIFVEVNATYYNSWQNLLYDSNGNLYGFRDYITNRTFMIRSCYSGRVSAA
FHANSSEPALLFRNIKCNYVFNNSLIRQLQPINYFDSYLGCVVNAYNSTA
ISVQTCDLTVGSGYCVDYSKNTTGYRFTNFEPFTVNSVNDSLEPVGGLYE
IQIPSEFTIGNMEEFIQTSSPKVTIDCAAFVCGDYAACKSQLVEYGSFCD
NINAILTEVNELLDTTQLQVANSLMNGVTLSTKLKDGVNFNVDDINFSSV
LGCLSSRSAIEDLLFDKVKLSDVGFVAAYNNCTGGAEIRDLICVQSYKGI
KVLPPLLSENQISGYTLAATSASLFPPWTAAAGVPFYLNVQYRINGLGVT
MDVLSQNQKLIANAFNNALDAIQEGFDATNSALVKIQAVVNANAEALNNL
LQQLSNRFGAISSSLQEILSRLDPPEAEAQIDRLINGRLTALNAYVSQQL
SDSTLVKFSAAQAMEKVNECVKSQSSRINFCGNGNHIISLVQNAPYGLYF
IHFSYVPTKYVTAKVSPGLCIAGDRGIAPKSGYFVNVNNTWMYTGSGYYY
PEPITENNVVVMSTCAVNYTKAPYVMLN
Ligand information
Ligand ID8Z9
InChIInChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h10-11H,2-9,12-15H2,1H3,(H,17,18)/b11-10-
InChIKeyNNNVXFKZMRGJPM-KHPPLWFESA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)CCCC\C=C/CCCCCCCCC
OpenEye OEToolkits 2.0.7CCCCCCCCCC=CCCCCC(=O)O
CACTVS 3.385CCCCCCCCC\C=C/CCCCC(O)=O
CACTVS 3.385CCCCCCCCCC=CCCCCC(O)=O
OpenEye OEToolkits 2.0.7CCCCCCCCC/C=C\CCCCC(=O)O
FormulaC16 H30 O2
NameSapienic acid
ChEMBL
DrugBank
ZINCZINC000085617707
PDB chain7sb3 Chain J Residue 1410 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7sb3 Structural mapping of antibody landscapes to human betacoronavirus spike proteins.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		N421 L422
Binding residue
(residue number reindexed from 1)		N391 L392
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0019062 virion attachment to host cell
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046718 symbiont entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0075509 endocytosis involved in viral entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane
GO:0044173 host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0055036 virion membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7sb3, PDBe:7sb3, PDBj:7sb3
PDBsum7sb3
PubMed35507649
UniProtA0A0B4N7I3

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