Structure of PDB 7s6m Chain A Binding Site BS01

Receptor Information

>7s6m Chain A (length=219) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFS
CFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAEKDKDSKLEKALKA
QNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFG
ALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFR
EISYLKKLKVKKQDRIFPP

Ligand information

>7s6m Chain O (length=5) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cgacg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7s6m Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.
Resolution	3.2 Å
Binding residue (original residue number in PDB)	E263 I266 F267 P336 E338
Binding residue (residue number reindexed from 1)	E123 I126 F127 P196 E198

Enzymatic activity

Enzyme Commision number

2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0008270	zinc ion binding

View graph for
Molecular Function

External links

PDB	RCSB:7s6m, PDBe:7s6m, PDBj:7s6m
PDBsum	7s6m
PubMed	35793673
UniProt	P09874\|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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