Structure of PDB 7s6h Chain A Binding Site BS01

Receptor Information
>7s6h Chain A (length=223) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFS
CFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAKSKKEKDKDSKLEK
ALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADG
MVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTP
KEFREISYLKKLKVKKQDRIFPP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7s6h Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		S16 R18 A19 R34 F44 V48 S274 G275
Binding residue
(residue number reindexed from 1)		S11 R13 A14 R29 F39 V43 S138 G139
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:7s6h, PDBe:7s6h, PDBj:7s6h
PDBsum7s6h
PubMed35793673
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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