Structure of PDB 7s0i Chain A Binding Site BS01

Receptor Information

>7s0i Chain A (length=387) Species: 1777792 (Influenza A virus (A/Michigan/45/2015(H1N1)))

SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRT
FFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSA
SACHDGINWLTIGISGPDSGAVAVLKYNGIITDTIKSWRNNILRTQESEC
ACVNGSCFTIMTDGPSDGQASYKIFRIEKGKIIKSVEMKAPNYHYEECSC
YPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQMGYICSGVFGDNPRPNDK
TGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRKGFEMIWDPNGWT
GTDNKFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRP
EENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTID

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 7s0i Chain A Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7s0i A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model.
• Resolution: 2.892 Å
• Binding residue (original residue number in PDB): D293 G297 D324 G345 N347
• Binding residue (residue number reindexed from 1): D213 G217 D243 G261 N263
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0046761 viral budding from plasma membrane

Cellular Component

• GO:0016020 membrane
• GO:0033644 host cell membrane
• GO:0055036 virion membrane

External links

• PDB: RCSB:7s0i, PDBe:7s0i, PDBj:7s0i
• PDBsum: 7s0i
• PubMed: 34809451
• UniProt: A0A0X9QTS2