Structure of PDB 7s05 Chain A Binding Site BS01

Receptor Information
>7s05 Chain A (length=437) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YHVLFDSYRDNIAGKSFQNRLCLPMPIDVVYTWVNGTDLELLKELQQVRE
QMEEEQKAMREILFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLN
LDNPRVTIVTHQDVFRNLSHLPTFSSPAIESHIHRIEGLSQKFIYLNDDV
MFGKDVWPDDFYSHSKGQKVYLTWPVTFADSLRYVNKILNSKFGFTSRKV
PAHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMS
AVQPLNISQVFDEVDTDQSGVLSDREIRTLATRIHELPLSLQDLTGLEHM
LINCSKMLESYYDPNLPPVTKSLVTNCKPVTDKIHKAYKDKNKYRFEIMG
EEEIAFKMIRTNVSHVVGQLDDIRKNPRKFVCLNDNIDHNHKDAQTVKAV
LRDFYESMFPIPSQFELPREYRNRFLHMHELQEWRAY
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7s05 Chain A Residue 1304 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7s05 Structure of the human GlcNAc-1-phosphotransferase alpha beta subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		D1018 D1020 V1024 E1029
Binding residue
(residue number reindexed from 1)		D265 D267 V271 E276
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.8.17: UDP-N-acetylglucosamine--lysosomal-enzyme N-acetylglucosaminephosphotransferase.
Gene Ontology
Molecular Function
GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0007040 lysosome organization
GO:0009306 protein secretion
GO:0016256 N-glycan processing to lysosome
GO:0033299 secretion of lysosomal enzymes
GO:0046835 carbohydrate phosphorylation
GO:0051649 establishment of localization in cell
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:7s05, PDBe:7s05, PDBj:7s05
PDBsum7s05
PubMed35332324
UniProtQ3T906|GNPTA_HUMAN N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (Gene Name=GNPTAB)

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