Structure of PDB 7rxq Chain A Binding Site BS01

Receptor Information
>7rxq Chain A (length=275) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAG
VYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSS
SSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVTET
YMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDGHREEGK
YQKVEHSVEGAQRAAAIARQKAEIAASRTSHAKAKAEAAEQAALAANQES
NIARTLARELAPDFYQPGPEYQKRR
Ligand information
>7rxq Chain B (length=15) Species: 9986 (Oryctolagus cuniculus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ERIFRRTGGLFGQVD
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7rxq Structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations.
Resolution2.03 Å
Binding residue
(original residue number in PDB)		F8 W18 G21 K22 C29 T30 G31 P32 W42 G45 F46 E47 W54 S56 N58 G67 R69 K77
Binding residue
(residue number reindexed from 1)		F8 W18 G21 K22 C29 T30 G31 P32 W42 G45 F46 E47 W54 S56 N58 G67 R69 K77
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Cellular Component
GO:0030314 junctional membrane complex

View graph for
Cellular Component
External links
PDB RCSB:7rxq, PDBe:7rxq, PDBj:7rxq
PDBsum7rxq
PubMed35238659
UniProtQ9BR39|JPH2_HUMAN Junctophilin-2 (Gene Name=JPH2)

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