Structure of PDB 7rtm Chain A Binding Site BS01

Receptor Information
>7rtm Chain A (length=571) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LFGGLVLDVKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLL
GEATEGRISAIESLFGASMTGIAYSLFAGQPLTILGSTGPVLVFEKILFK
FCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASL
ICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCALPENPNNHTLQ
YWKEHSIPTADVNWANLTVSECQEMHGEFIGSACGHHGPYTPDVLFWSCI
LFFATFIVSSTLKTFKTSRYFPTRVRSTVSDFAVFLTIFTMVILDFLIGV
PSPKLQVPSVFKPTRDDRGWFISPIGPNPWWTVIAAIIPALLCTILIFMD
QQITAVIINRKEHKLKKGCGYHLDLLVVAIMLGVCSLMGLPWFVAATVLS
ITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAVLK
FIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLR
KVHLFTLVQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMDLCFSKRE
LSWLDDLMPESKKKKLDDAKK
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain7rtm Chain A Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7rtm Cryo-EM structure of the sodium-driven chloride/bicarbonate exchanger NDCBE.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		D800 T804 A845 A846
Binding residue
(residue number reindexed from 1)		D350 T354 A395 A396
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005452 solute:inorganic anion antiporter activity
Biological Process
GO:0006820 monoatomic anion transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7rtm, PDBe:7rtm, PDBj:7rtm
PDBsum7rtm
PubMed34584093
UniProtQ6RVG2|S4A8_RAT Electroneutral sodium bicarbonate exchanger 1 (Gene Name=Slc4a8)

[Back to BioLiP]