Structure of PDB 7rtj Chain A Binding Site BS01

Receptor Information
>7rtj Chain A (length=398) Species: 154 (Spirochaeta thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TYTLVWKVWILAVTLYFAIRIPLTLVFPSLFSPLLPLDILASLALIADIP
LDLLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSA
TRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLS
AFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLV
SKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEE
REVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIY
GPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALI
LRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRRKE
Ligand information
Ligand IDCMP
InChIInChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
InChIKeyIVOMOUWHDPKRLL-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C4C(O3)COP(=O)(O4)O)O)N
ACDLabs 10.04O=P3(OCC4OC(n1c2ncnc(N)c2nc1)C(O)C4O3)O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@H]4[C@H](O3)CO[P@](=O)(O4)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH]4CO[P](O)(=O)O[CH]4[CH]3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4CO[P@](O)(=O)O[C@H]4[C@H]3O
FormulaC10 H12 N5 O6 P
NameADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE;
CYCLIC AMP;
CAMP
ChEMBLCHEMBL316966
DrugBankDB02527
ZINCZINC000003873977
PDB chain7rtj Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7rtj Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		Y357 F366 G367 E368 R377 R418
Binding residue
(residue number reindexed from 1)		Y335 F344 G345 E346 R355 R396
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity
GO:0044877 protein-containing complex binding
Biological Process
GO:0034220 monoatomic ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7rtj, PDBe:7rtj, PDBj:7rtj
PDBsum7rtj
PubMed36376326
UniProtG0GA88

[Back to BioLiP]