Structure of PDB 7rk3 Chain A Binding Site BS01

Receptor Information
>7rk3 Chain A (length=352) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSP
EFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVE
INFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTC
RYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETK
DIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEV
TDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKM
KGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLV
LQ
Ligand information
Receptor-Ligand Complex Structure
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PDB7rk3 Crystal structure of human N-myristoyltransferase 1 fragment (residues 109-496) bound to diacylated human Arf6 octapeptide and Coenzyme A
Resolution2.05 Å
Binding residue
(original residue number in PDB)		Y180 V181 D183 D185 F188 R189 F190 Y192 T282 G284 Y296 H298 F311 S312 I469 G470 D471 G472 L474
Binding residue
(residue number reindexed from 1)		Y36 V37 D39 D41 F44 R45 F46 Y48 T138 G140 Y152 H154 F167 S168 I325 G326 D327 G328 L330
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.97: glycylpeptide N-tetradecanoyltransferase.
Gene Ontology
Molecular Function
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
Biological Process
GO:0006499 N-terminal protein myristoylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7rk3, PDBe:7rk3, PDBj:7rk3
PDBsum7rk3
PubMed
UniProtP30419|NMT1_HUMAN Glycylpeptide N-tetradecanoyltransferase 1 (Gene Name=NMT1)

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