Structure of PDB 7ri0 Chain A Binding Site BS01

Receptor Information

>7ri0 Chain A (length=430) Species: 330879 (Aspergillus fumigatus Af293)

PISKIHARSVYDSRGNPTVEVDVVTETGLHRAIVPSGASTGQHEAHELRD
GDKTQWGGKGVLKAVKNVNETIGPALIKENIDVKDQSKVDEFLNKLDGTA
NKSNLGANAILGVSLAVAKAGAAEKGVPLYAHISDLAGTKKPYVLPVPFQ
NVLNGGSHAGGRLAFQEFMIVPDSAPSFSEALRQGAEVYQKLKALAKKKY
GQSAGNVGDEGGVAPDIQTAEEALDLITEAIEQAGYTGKIKIAMDVASSE
FYKADVKKYDLDFKKWLTYEQLADLYKSLAAKYPIVSIEDPFAEDDWEAW
SYFYKTSDFQIVGDDLTVTNPGRIKKAIELKSCNALLLKVNQIGTLTESI
QAAKDSYADNWGVMVSHRSGETEDVTIADIAVGLRSGQIKTGAPCRSERL
AKLNQILRIEEELGENAVYAGSKFRTAVNL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7ri0 Chain A Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ri0 A structural model of the human plasminogen and Aspergillus fumigatus enolase complex.
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): D246 E297 D322
• Binding residue (residue number reindexed from 1): D245 E289 D314
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 4.2.1.11: phosphopyruvate hydratase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004634 phosphopyruvate hydratase activity
• GO:0016829 lyase activity
• GO:0019863 IgE binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006096 glycolytic process

Cellular Component

• GO:0000015 phosphopyruvate hydratase complex
• GO:0005737 cytoplasm

External links

• PDB: RCSB:7ri0, PDBe:7ri0, PDBj:7ri0
• PDBsum: 7ri0
• PubMed: 35247004
• UniProt: Q96X30|ENO_ASPFU Enolase (Gene Name=enoA)