Structure of PDB 7rhw Chain A Binding Site BS01

Receptor Information
>7rhw Chain A (length=437) Species: 330879 (Aspergillus fumigatus Af293) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PISKIHARSVYDSRGNPTVEVDVVTETGLHRAIVPSGASTGQHEAHELRD
GDKTQWGGKGVLKAVKNVNETIGPALIKENIDVKDQSKVDEFLNKLDGTA
NKSNLGANAILGVSLAVAKAGAAEKGVPLYAHISDLAGTKKPYVLPVPFQ
NVLNGGSHAGGRLAFQEFMIVPDSAPSFSEALRQGAEVYQKLKALAKKKY
GQSAGNVGDEGGVAPDIQTAEEALDLITEAIEQAGYTGKIKIAMDVASSE
FYKADVKKYDLDFKNPESDPSKWLTYEQLADLYKSLAAKYPIVSIEDPFA
EDDWEAWSYFYKTSDFQIVGDDLTVTNPGRIKKAIELKSCNALLLKVNQI
GTLTESIQAAKDSYADNWGVMVSHRSGETEDVTIADIAVGLRSGQIKTGA
PCRSERLAKLNQILRIEEELGENAVYAGSKFRTAVNL
Ligand information
Ligand ID2PG
InChIInChI=1S/C3H7O7P/c4-1-2(3(5)6)10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1
InChIKeyGXIURPTVHJPJLF-UWTATZPHSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(C(=O)O)OP(=O)(O)O)O
ACDLabs 10.04O=P(O)(O)OC(C(=O)O)CO
OpenEye OEToolkits 1.5.0C([C@H](C(=O)O)OP(=O)(O)O)O
CACTVS 3.341OC[C@@H](O[P](O)(O)=O)C(O)=O
CACTVS 3.341OC[CH](O[P](O)(O)=O)C(O)=O
FormulaC3 H7 O7 P
Name2-PHOSPHOGLYCERIC ACID
ChEMBL
DrugBankDB01709
ZINCZINC000003869232
PDB chain7rhw Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7rhw A structural model of the human plasminogen and Aspergillus fumigatus enolase complex.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		A39 S40 H159 Q167 E168 E211 D246 D322 K347 H375 R376 S377 K398
Binding residue
(residue number reindexed from 1)		A38 S39 H158 Q166 E167 E210 D245 D321 K346 H374 R375 S376 K397
Annotation score5
Enzymatic activity
Enzyme Commision number 4.2.1.11: phosphopyruvate hydratase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0016829 lyase activity
GO:0019863 IgE binding
GO:0046872 metal ion binding
Biological Process
GO:0006096 glycolytic process
Cellular Component
GO:0000015 phosphopyruvate hydratase complex
GO:0005737 cytoplasm

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rhw, PDBe:7rhw, PDBj:7rhw
PDBsum7rhw
PubMed35247004
UniProtQ96X30|ENO_ASPFU Enolase (Gene Name=enoA)

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