Structure of PDB 7rg5 Chain A Binding Site BS01

Receptor Information
>7rg5 Chain A (length=416) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVH
CLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQ
NVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVT
WVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTD
AGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQV
VLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVP
MIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLT
VKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENE
DIYKLAYEIIDQFFSS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7rg5 MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		R96 S100 D102 R103 W137 N141 S144 G145 T146 T150 Q176 W179 N183 G186 W222 N226 R229
Binding residue
(residue number reindexed from 1)		R25 S29 D31 R32 W66 N70 S73 G74 T75 T79 Q105 W108 N112 G115 W151 N155 R158
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rg5, PDBe:7rg5, PDBj:7rg5
PDBsum7rg5
PubMed35338144
UniProtO00629|IMA3_HUMAN Importin subunit alpha-3 (Gene Name=KPNA4)

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