Structure of PDB 7rg2 Chain A Binding Site BS01

Receptor Information
>7rg2 Chain A (length=425) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYF
Ligand information
>7rg2 Chain B (length=11) Species: 1335626 (Middle East respiratory syndrome-related coronavirus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ARKRSTKKLAY
Receptor-Ligand Complex Structure
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PDB7rg2 MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		S105 E107 W142 N146 A148 S149 G150 T155 W184 N188 D192 W231 R238 V321 T322 W357 N361 A364 E396 W399 S406
Binding residue
(residue number reindexed from 1)		S34 E36 W71 N75 A77 S78 G79 T84 W113 N117 D121 W160 R167 V250 T251 W286 N290 A293 E325 W328 S335
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rg2, PDBe:7rg2, PDBj:7rg2
PDBsum7rg2
PubMed35338144
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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